Lymphocyte and macrophage activation

Videonummer 11938289
Lymphocyte and macrophage activation. Animation showing the immune system mechanism by which T-lymphocytes differentiate and activate macrophages. Both these cells are types of white blood cell, part of the immune response. The animation starts with a dendritic cell (green, upper left) which migrated from a periphery lymphoid organ. It has processed a bacterial antigen and presents a major histocompatibility complex class II (MHC II) molecule (orange) that is shown binding to a T cell receptor (green). This T cell is a T-helper cell (Th cell). The dendritic cell secretes an interleukin signalling molecule (IL-12) which triggers the differentiation of the Th cell into a Th1 cell. This activated lymphocyte, enriched by antigenic receptor and accessory membrane molecules like the CD40 ligand (green), is then shown binding to a macrophage (purple, lower right). The macrophage has previously engulfed bacteria (red). Its activation by the Th cell helps it to produce antibacterial products that are shown destroying the bacteria. This process is largely facilitated by secretion of substances like gamma-interferon (grey dots, shown binding to a receptor at bottom right) or tumour necrosis factor (not shown here). Additional receptors (orange) are also produced. For this animation with labels, see K004/4165.
Lizenzart: Lizenzpflichtig
Credit: Science Photo Library / Biocosmos / Francis Leroy & Marie Martinache
Modell-Rechte: nicht erforderlich
Länge: 40 Sekunden
Seitenverhältnis: 16:9
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