Antigen presentation by macrophage

Videonummer 11938286
Antigen presentation by macrophage. Animation showing exogenous antigen presentation by a macrophage (grey) to a T helper cell (orange, top). The nuclei of both cells are shown. The animation starts with a bacterium (red, upper left) being ingested by the macrophage, a type of white blood cell that specialises in this role. The endosome containing the bacterium is then fuses with a lysosome (yellow) that contains enzymes (blue dots) that break down and destroy the bacterium. The bacterial proteins are degraded into short peptides (red dots). Another fusion then takes place, with an endoplasmic network compartment (white) containing a major histocompatibility complex class II (MHC II) molecule (blue). This MHC II molecule is stabilised by a protein (red) that is degraded once fusion with the lysosome has occurred. This allows the MHC II molecule to bind to one of the bacterial peptide fragments. The resulting MHC II–bacterial peptide complex is transported to the cell membrane and the antigen is presented on the surface where it binds to a T helper cell receptor (green). This triggers further responses that regulate the immune response to the bacterial infection. For this animation without labels, see K004/4164.
Lizenzart: Lizenzpflichtig
Credit: Science Photo Library / Biocosmos / Francis Leroy & Marie Martinache
Modell-Rechte: nicht erforderlich
Länge: 33 Sekunden
Seitenverhältnis: 16:9
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