Regulation of glycolysis

Videonummer 11937602
Regulation of glycolysis. Animation showing a mechanism for the regulation of the cycle of glycolysis (metabolism of glucose, upper left) which is supplying the Krebs cycle (citric acid cycle, upper right) with acetyl-coenzyme A (acetyl-CoA). These are key components of the process of respiration, generating energy at a cellular level. The first stage of the animation shows the intermediate steps (phosphofructoses and pyruvate) between glucose and acetyl-CoA. The phosphofructoses are fructose-6-phosphate (far left) and fructose-1, 6-bisphosphate (centre left). Four processes are shown branching off the Krebs cycle. At top right is an electron transport chain to ATP (adenosine triphosphate), with ATP also produced directly (upper left). At centre right is the reduced nicotinamide adenine dinucleotide (NADH) pathway leading to pyruvate dehydrogenase. A fourth pathway leads to a key enzyme phosphofructokinase (lower left). This exerts an inhibitory effect controlled by the concentration of ATP and citrate. When these concentrations fall below a certain level, adenosine diphosphate (ADP) activates the enzyme, which plays a key regulatory role by catalysing the phosphorylation of fructose-6-phosphate to fructose-1, 6- bisphosphate. For this animation without labels, see K004/3309.
Lizenzart: Lizenzpflichtig
Credit: Science Photo Library / Biocosmos / Francis Leroy & Edwin Vandermeeren
Modell-Rechte: nicht erforderlich
Länge: 39 Sekunden
Seitenverhältnis: 16:9
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