Phosphinositide cascade, animation
Videonummer 11937576
| Phosphinositide cascade, animation. The binding of a hormone (green sphere) to a receptor (pink) in the plasma membrane of a cell activates a G protein (orange). The G protein in turn activates phosphlipase C (yellow) a transmembrane enzyme that hydrolyses PIP2 (red) to inositol trisphosphate (IP3) and diacylglycerol (DAG, purple). Both of these substances act as second messengers, activating protein kinase C (brown). IP3 does this by stimulating the release of calcium ions (red spheres) from the endoplasmic reticulum (bottom). This increase in calcium ions activates protein kinase C. DAG activates it directly. Once activated protein kinase C can phosphorylate a number of proteins (red) to bring about a number of effects depending upon the cell. | |
| Lizenzart: | Lizenzpflichtig |
| Credit: | Science Photo Library / Biocosmos / Francis Leroy & Nathan Petit |
| Modell-Rechte: | nicht erforderlich |
| Länge: | 01:09 Minuten |
| Seitenverhältnis: | 16:9 |
| Restrictions: | - |
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