Ferritin and cellular iron response

Videonummer 11936740
Ferritin and cellular iron response. Animation showing the mechanisms involved in the storage of iron in cells. Ferritin is a protein that stores iron. The opening stages of the animation shows across bottom the mRNA (messenger ribonucleic acid) strand that contains the instructions for the synthesis of ferritin. This process (translation) is carried out by a structure called a ribosome (blue). The mRNA strand that encodes ferritin contains an iron-response element (rounded loop at left) near its 5' cap. When iron (red spheres) is scarce, a protein called aconitase (green) binds to the iron-response element, blocking translation of the mRNA. In the presence of adequate supplies of iron, the iron binds to the aconitase and removes it, allowing translation of the mRNA to proceed normally. The animation shows the ribosome producing the protein ferritin (yellow strand) to store the iron. Labelled here is the AUG start codon for the transcription process. For this animation with labels, see K004/2054.
Lizenzart: Lizenzpflichtig
Credit: Science Photo Library / Biocosmos / Francis Leroy & Valentin Legrand
Modell-Rechte: nicht erforderlich
Länge: 28 Sekunden
Seitenverhältnis: 16:9
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