T lymphocyte activation in immune response. Animation showing the cellular mechanisms by which T lymphocytes, a type of white blood cell, are activated during an immune response. At top left, a virus (red) has triggered an antigen presenting cell (APC, purple), which is presenting the resulting antigens to a T helper cell (Th cell, blue). Also labelled are an infected cell (lower left, white, containing virus particles), and the receptors (various colours). The MHC (major histocompatibility complex) receptors are orange (MHC II) and yellow (MHC I). The CD (cluster of differentiation) markers are green (CD4 and CD8). Also at lower left is a T cytotoxic cell (Tc cell, orange). As the labels fade out, the first stage in the animation is the Th cell attaching to the APC cell. This is followed by the Tc cell attaching to the infected cell. The secretion of interleukin (a signalling chemical) prompts the activation of more Tc cells that attach to and destroy infected cells (far right). For this animation without labels, see K004/1993. |