DNA repair mechanism. Animation showing how a damaged base in a sequence of DNA (deoxyribonucleic acid) is repaired. The bases (yellow, ACGT) are attached to a sugar-phosphate backbone (grey). The first stage of the clip shows a mutation event (arrow) resulting in a damaged base (red). This is followed by the excision of the damaged base by a DNA glycosylase enzyme. The next step is the breaking of the sugar-phosphate backbone by an endonulease enzyme (green). The resulting gap is enlarged by an exonuclease enzyme (blue). The gap is then filled by the synthesis of a complementary strand (red) by a polymerase enzyme (yellow square). The final stage is the rejoining of the sugar-phosphate backbone by a ligase enzyme (white). For this animation with labels, see K004/0958. | |
Lizenzart: | Lizenzpflichtig |
Credit: | Science Photo Library / Biocosmos / Francis Leroy & Mathilde Vanspeybrouck |
Modell-Rechte: | nicht erforderlich |
Länge: | 50 Sekunden |
Seitenverhältnis: | 16:9 |
Restrictions: | - |