Breakdown of misfolded proteins, animation

Videonummer 11936418
Breakdown of misfolded proteins, animation. This is the ubiquitin-proteasome system. In normal protein synthesis, chains of amino acids are folded into specific shapes to form proteins. Sometimes this process malfunctions, and proteins are misfolded. Misfolded proteins will either be ineffective in their role or toxic to the body. The ubiquitin-proteasome system detects misfolded proteins and breaks them down. First, a ubiquitin-activating enzyme (E1) binds to a ubiquitin molecule (U) using energy from ATP (adenosine triphosphate). E1 transfers U to a ubiquitin-conjugating enzyme (E2). A ubiquitin ligase complex (E3) recognises the misfolded protein (beige strand) and transfers U from E2 to the protein. E3 adds several ubiquitin molecules to the misfolded protein, effectively 'tagging' it for recognition by a proteasome. A proteasome is a protein complex that recognises chains of ubiquitin and breaks down the protein attached to it into individual amino acids, ready to be assembled into another protein.
Lizenzart: Lizenzpflichtig
Credit: Science Photo Library / Biocosmos / Francis Leroy & Guillaume Wilmotte
Modell-Rechte: nicht erforderlich
Länge: 51 Sekunden
Seitenverhältnis: 16:9
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