Illustration of a receptor for advanced glycation endproducts (RAGE) within a lipid bilayer membrane. This transmembrane protein belongs to the immunoglobulin superfamily and is able to bind to multiple molecules. Binding results in a signal cascade that causes pro-inflammatory gene activation. The expression of RAGE is stimulated by cellular stresses, such as inflammation, and so this leads to a positive feedback cycle that results in chronic inflammation. RAGE is involved in the pathogenesis of a number of diseases including diabetes, Alzheimer's disease and cancers. | |
Lizenzart: | Lizenzfrei |
Credit: | Science Photo Library / THOM LEACH |
Modell-Rechte: | nicht erforderlich |
Eigentums-Rechte: | nicht erforderlich |
Restrictions: | - |