James P. Allison, US immunologist. illustration

Bildnummer 13951930
James P. Allison, US immunologist. illustration
Illustration of the US immunologist James P. Allison (born 1948). Allison is best known for his work on T cells (a white blood cell of the immune system) and immune system tumour recognition. In the early 1980s he discovered the T cell antigen receptor, the protein the cells use to recognise foreign substances and cancerous cells. Further work showed that the molecule CD28 was required for T cell activation and that CD28 was regulated by an immune checkpoint molecule (CTLA-4) to prevent it attacking healthy cells. Some cancer cells take advantage of CTLA-4 to avoid detection by T cells. Allison showed that blocking CTLA-4 enhanced T cell response to cancers and lead to tumour shrinkage and developed the first immune checkpoint blockade therapy to treat cancer. Allison was awarded a share of the 2018 Nobel Prize in Physiology or Medicine for this work along with Tasuku Honjo.
Lizenzart: Lizenzpflichtig
Credit: Science Photo Library / Brown, Gary
Bildgröße: 2928 px × 3940 px
Modell-Rechte: nicht erforderlich
Eigentums-Rechte: nicht erforderlich
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