Fibrodysplasia ossificans progressiva mutant protein

Bildnummer 13504776
Fibrodysplasia ossificans progressiva mutant protein
Molecular model of a mutant copy of the activin A receptor type I (ACVR1) protein (brown and light pink) that causes the rare genetic disease fibrodysplasia ossificans progressiva (FOP). FOP is a disease where fibrous tissues, including muscle, tendons and ligaments, are gradually replaced by bone (ossified). A mutation in the ACVR1 gene, which plays a role in the bone morphogenic protein (BMP) pathway, leads to a change in amino acid at position 206, where arginine is swapped for histidine (rod shaped). This decreases the affinity of the ACVR1 protein for its inhibitor FK506-binding protein 12 (FKB12, yellow), leading to increased activity of the protein and therefore increased production of bone.
Lizenzart: Lizenzpflichtig
Credit: Science Photo Library / Andrade, Ramon / 3dciencia
Bildgröße: 3520 px × 4977 px
Modell-Rechte: nicht erforderlich
Eigentums-Rechte: nicht erforderlich
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