GLIC receptor complexed with DHA, molecular model
Bildnummer 13435182
| Molecular model of prokaryotic GLIC synaptic receptor (Gloeobacter Ligand-gated Ion Channel, grey) complexed with omega-3 fatty acid docosahexaenoic acid (DHA, yellow spheres). When a neurotransmitter binds to a channel, GLICs allow for ions to pass through a channel. However, when DHA binds to GLIC, it conforms the ion channel into a desensitised state. Desensitization occurs when an ion channel tends to close despite a neurotransmitter being bound to it. In this case, desensitization occurs because the DHA molecule binds close to the M4 helix (blue) to a site at the edge of the channel causing a change in the structure of GLIC. This leaves the upper part of the channel open while the lower part is constricted and closed, enhancing channel desensitization. Understanding channel desensitization, could allow development of drugs that target desensitized ion channels. | |
| Lizenzart: | Lizenzpflichtig |
| Credit: | Science Photo Library / Andrade, Ramon / 3dciencia |
| Bildgröße: | 3653 px × 4870 px |
| Modell-Rechte: | nicht erforderlich |
| Eigentums-Rechte: | nicht erforderlich |
| Restrictions: | - |
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