Haemangioblastoma, light micrograph

Bildnummer 13296463
Haemangioblastoma, light micrograph
Haemangioblastoma, light micrograph. Hemangioblastoma is a WHO Grade I tumour that may occur sporadically or in the setting of von Hippel Lindau disease (about 25% of patients). The peak incidence is seen in the 3rd and 4th decades. The most common location is cerebellum. On MRI with contrast, the tumour usually appears a sharply demarcated enhancing mass with cystic areas in the cerebellum. This appearance is seen in about 60% of cases; remaining 40% of cases are entirely solid. About 10-25% of patients with hemangioblastoma carry a germline mutation in the VHL gene. Grossly, hemangioblastomas are generally well circumscribed with solid and cystic components. They are usually dark red-brown given extensive vascularity. This high magnification image of a hemangioblastoma shows stromal cells with abundant vacuolated or lightly eosinophilic cytoplasm. Mitotic activity is generally not increased; but occasional mitotic figures may be present (as shown here). Necrosis is not a prominent feature.
Lizenzart: Lizenzpflichtig
Credit: Science Photo Library / WEBPATHOLOGY
Bildgröße: 4096 px × 3200 px
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