Spindle cell rhabdomyosarcoma, light micrograph

Bildnummer 13243838
Spindle cell rhabdomyosarcoma, light micrograph
Spindle cell rhabdomyosarcoma, light micrograph. Rhabdomyosarcoma (RMS) is a malignant soft tissue tumour that shows skeletal muscle differentiation. There is no evidence it arises from skeletal muscle cells. Many cases occur at sites with scant or no skeletal muscle tissue. RMS can occur anywhere in the body, but affects three regions more commonly - the head and neck, genitourinary tract and retroperitoneum, and upper and lower extremities. The World Health Organization recognizes four major types of rhabdomyosarcomas - embryonal, alveolar, pleomorphic and spindle cell/sclerosing type. Spindle cell and sclerosing rhabdomyosarcomas are related entities and show overlapping morphologic and molecular genetic features (MYOD1 mutations). They make up 5% to 10% of all rhabdomyosarcomas and carry a favourable prognosis. The image shows spindle cell rhabdomyosarcoma which is composed of relatively uniform population of spindle cells.
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Credit: Science Photo Library / WEBPATHOLOGY
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