Proteasome,illustration

Bildnummer 12897036
Proteasome,illustration
Proteasome,illustration. Proteasomes are large protein-digesting molecular machines that degrade unneeded or damaged proteins (red) that have been tagged with polyubiquitin (a chain of multiple ubiquitin molecules,yellow). This protein degradation process is called proteolysis. Each proteasome complex consists of a hollow catalytic core (20S,blue),where the unfolded protein is threaded through,and its degradation takes place. There is a regulatory cap (19S) at the top of the complex which contains a ubiquitin hydrolase (purple),which recognises the polyubiquitin-tagged proteins,and detaches the ubiquitin molecules from the protein. The protein is then unfolded and transferred to the hollow catalytic core for degradation into smaller peptides (red,bottom).
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Credit: Science Photo Library / Gaertner, Juan
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