Peripheral T-cell lymphoma,light micrograph. In peripheral T-cell lymphoma,not otherwise specified,the tumour cells are variably-sized and consists of small cells with only minimal cytologic atypia and larger cells with irregular nuclear contours,prominent nucleoli,and brisk mitotic activity. Large cells with clear cytoplasm and Reed-Sternberg-like cells may be seen in some cases. Evidence of neoangiogenesis in the form of high endothelial venules is often seen. There is often a prominent component of reactive cells in the background,including small lymphocytes,eosinophils,macrophages,and plasma cells. |