ATP in an Active SIte, molecular model
Bildnummer 12652439
| ATP, the biomolecule responsible for cellular energy distribution, is usually accompanied by two magnesium ions. These cations stabilize the cumulative 4 - charge of the ATP triphosphate group. In doing so, the magnesium ions also activate ATP as a phosphorylating agent, stabilizing the negative charge makes ATP a better substrate for nucleophilic attack, and it makes ADP a better leaving group. This figure shows a model of ATP in its binding site in one of the kinase enzymes of glycolysis. The Mg(2+) ions (green) are held in place by electrostatic interactions (purple) between the triphosphate oxygen atoms and the carboxyl groups of several Asp residues. Hydrogen bonds to the sugar and the phosphate group are also important, as is the dispersion interaction between the adenine electron cloud and an Ile sidechain. | |
| Lizenzart: | Lizenzpflichtig |
| Credit: | Science Photo Library / Science Source / Greg Williams |
| Bildgröße: | 5400 px × 4200 px |
| Modell-Rechte: | nicht erforderlich |
| Eigentums-Rechte: | nicht erforderlich |
| Restrictions: | - |
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