Coeliac disease mechanism, illustration

Bildnummer 12362788
Coeliac disease mechanism, illustration
Coeliac disease mechanism. Illustration of the mechanism by which gluten affects the intestines of those with the autoimmune disorder coeliac disease. Nine stages are shown here, relating to the enterocytes (intestinal absorptive cells) and the underlying intestinal epithelium layer (across centre). The presence of indigestible gluten fragments (upper left) causes the enterocytes to produce the protein zonulin, which then causes junctions to open between the cells and the gluten to pass down to the epithelium. A cascade of autoimmune responses follows that causes progressive and increasingly severe damage to the intestines (far right). This involves the protein IL-15, the enzyme transglutaminase (tTG), and the body's own white blood cells, here lymphocytes, T lymphocytes and B lymphocytes.
Lizenzart: Lizenzpflichtig
Credit: Science Photo Library / JOSE ANTONIO PENAS
Bildgröße: 5139 px × 2480 px
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