Genetically engineered t-cell
Bildnummer 12033530
| Genetically engineered T-cell attacking a cancer cell. Chimeric antigen receptors (CAR) are genetically engineered from specific monoclonal antibodies. These fusion receptors are comprised of a targeting portion (in this case,a single chain antibody),coupled via a hinge and transmembrane element to a modular signalling domain. This is a third generation CAR in which signalling and additional stimulation is provided by a T-cell receptor complex,CD28 and a tumour necrosis factor receptor (TNFr). Contact between the MHC peptide and the TCR triggers the release and exocytosis of granzymes from cytotoxic granules. along with exogenous administration of IL-2 to further boost their anti-cancer activity. Labelled | |
| Lizenzart: | Lizenzpflichtig |
| Credit: | Science Photo Library / Carol and Mike Werner |
| Bildgröße: | 6060 px × 4040 px |
| Modell-Rechte: | nicht erforderlich |
| Eigentums-Rechte: | nicht erforderlich |
| Restrictions: |
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