Philadelphia chromosome. Coloured light micrograph of a female karyotype (chromosome set) with one defective chromosome each from pairs 9 and 22. The defects,on the right-hand chromosomes of the two pairs,cause chronic myelogenous leukaemia (CML). The 46 chromosomes of a human karyotype are here arranged in 23 pairs of a maternal and paternal chromosome. The left-hand chromosomes of pairs 22 and 9 are normal,whereas an exchange of material (translocational defect) made defective chromosome 9 larger and shrunk defective chromosome 22. In a bone marrow stem cell,the chromosome 22 defect causes the CML increased white blood cell count | |
Lizenzart: | Lizenzpflichtig |
Credit: | Science Photo Library / Addenbrookes Hospital / Dept. of Clinical Cytogenetics |
Bildgröße: | 3996 px × 2854 px |
Modell-Rechte: | nicht erforderlich |
Eigentums-Rechte: | nicht erforderlich |
Restrictions: | - |