K-Ras PI3K complex

Bildnummer 11722047
K-Ras PI3K complex
K-Ras PI3K complex. Computer model showing the structure of a molecule of the K-Ras oncogene protein (white,right) in complex with benzamidine (spheres,right) and four domains of the PI3K (phosphoinositide 3-kinase) gamma subunit. RBD (red),C2 domain (pale green),helical domain (yellow),and N- and C-terminal lobes of the catalytic domain (purple and pink) are shown. The location of the g phosphate of the ATP PI3K gamma structure is marked with a large phosphate molecule (orange and red spheres). Ras proteins are involved in transmitting signals within cells. They are GTPase enzymes - they bind and hydrolyze GTP. Mutations in the K-Ras gene is an essential step in the development of many cancers,therefore this protein is classed as an oncogene protein. Ras inhibitors such as benzamidine are being studied as a treatment for cancer
Lizenzart: Lizenzpflichtig
Credit: Science Photo Library / Andrade, Ramon / 3dciencia
Bildgröße: 4859 px × 3644 px
Modell-Rechte: nicht erforderlich
Eigentums-Rechte: nicht erforderlich
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