Stimulatory G protein. Animation showing the mechanism by which a stimulatory G protein (red and yellow) mediates the activation of adenylate cyclase (blue) and the opening of a membrane channel (brown). A hormone molecule (orange) binds to its receptor (purple), forming a hormone-receptor complex. This complex binds to the G protein and induces the release of GDP (guanosine diphosphate) from the protein. This allows GTP (guanosine triphosphate) to bind to the G protein instead, causing the alpha subunit (red) of the G protein to disassociate from the beta/gamma subunit (yellow). The alpha subunit-GTP complex then activates adenylate cyclase. Adenylate cyclase is an enzyme that catalyses the formation of cAMP (cyclic adenosine monophosphate, pink), a secondary messenger. Here cAMP then activates a ligand that binds to a membrane channel, which opens it. For a version of this clip with text, see K004/0317. | |
Lizenzart: | Lizenzpflichtig |
Credit: | Science Photo Library / Biocosmos / Francis Leroy & Maxime Deroyer |
Modell-Rechte: | nicht erforderlich |
Länge: | 25 Sekunden |
Seitenverhältnis: | 16:9 |
Restrictions: | - |