Craniopharyngioma, light micrograph. Craniopharyngioma is a WHO Grade 1 epithelial tumour usually seen in the sellar/suprasellar region. It arises most likely from the remnants of Rathke's pouch. Some cases may have their origin in misplaced odontogenic rests along pituitary stalk. Grossly, they are often solid and cystic with areas of calcification. Craniopharyngiomas are subdivided into two types based on morphologic features: 1) Adamantinomatous (90% of cases) seen mostly in children and 2) Papillary (10% of cases) seen mostly in adults. The image shows adamantinomatous type with most of the key diagnostic features: a) sheets of squamous epithelial cells with peripheral palisading (which is best seen along the top of the image); b) a loose meshwork of epithelial cells called the stellate reticulum; c) nodules of anucleated squames (ghost cells) with brightly eosinophilic cytoplasm termed wet keratin. Wet keratin is considered diagnostic even in the absence of viable epithelium. | |
Lizenzart: | Lizenzpflichtig |
Credit: | Science Photo Library / WEBPATHOLOGY |
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